Wegovy® is an injectable prescription medicine to treat adults with metabolic dysfunction-associated steatohepatitis (MASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver, along with a reduced calorie diet and increased physical activity. This indication is approved based on improvement of MASH and liver scarring (fibrosis). There is an ongoing study to confirm the clinical benefit of Wegovy® in adults with MASH.
Frequently asked questions
If you’re thinking about starting Wegovy® to help manage MASH, you’re bound to have questions. While your health care professional (HCP) is always the best resource, this information can help answer some common questions you may have.
MASH, metabolic dysfunction–associated steatohepatitis.
On this page:
About Wegovy®
Wegovy® is an injectable prescription medicine to treat adults with metabolic dysfunction–associated steatohepatitis (MASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver.
Wegovy® should be used with a reduced calorie meal plan and increased physical activity.
Wegovy® contains semaglutide and should not be used with other semaglutide-containing products or other GLP-1 receptor agonist medicines.
Wegovy® is indicated for adults with MASH with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver.
The most common side effects of Wegovy® in adults may include nausea, diarrhea, vomiting, constipation, stomach (abdomen) pain, headache, tiredness (fatigue), upset stomach, dizziness, feeling bloated, belching, low blood sugar in people with type 2 diabetes, gas, stomach flu, and heartburn. Tell your HCP if you have any side effects that does not go away or bothers you.
People respond to medicines differently, so there is no set time for when you can expect to see results with Wegovy®. Ask your HCP about what might be realistic for you and your MASH management journey.
Taking Wegovy®
Wegovy® is taken once a week, any time of day, with or without food. It is a self-administered injection under the skin of your stomach (abdomen), thigh, or upper arm.
Wegovy® comes in 5 different doses: 0.25 mg, 0.5 mg, 1 mg, 1.7 mg, and 2.4 mg. Each dose comes in its own color pen.
Yes, it’s recommended that you take Wegovy® on the same day every week at a time that is most convenient for you.
Take Wegovy® 1 time each week, on the same day each week, at any time of the day. You may change the day of the week or the time of the day you take Wegovy®, as long as your last dose was given 2 or more days before.
If the next scheduled dose is more than 2 days away (48 hours), take the missed dose as soon as possible.
If the next scheduled dose is less than 2 days away (48 hours), do not administer the dose. Take your next dose on the regularly scheduled day.
If you miss doses of Wegovy® for 2 or more weeks, take the next dose on the regularly scheduled day or call your HCP to talk about how to restart your treatment.
You can take Wegovy® with or without food.
If your pen isn't working correctly, do not use it. Call 1-833-4-WEGOVY or contact your HCP.
Do not use Wegovy® if it is not clear and colorless. Safely throw away the Wegovy® pen and contact our Patient Customer Care Center at 833-934-6891 for a replacement.
It’s normal to feel nervous injecting yourself for the first time. You’re not alone! Your HCP is a good resource for guidance when it comes to injecting Wegovy®. You may also refer to the written Wegovy® Instructions for Use.
It’s always important to properly throw away your used Wegovy® pen. After injecting your Wegovy® dose, do not throw away the pen in your household trash or recycling bin. Instead, use either
- An FDA-cleared sharps disposal container
- A sturdy household container with a tight-fitting lid, like a heavy-duty plastic container. Make sure the container is properly labeled to warn of hazardous waste inside the container
You can request a complimentary sharps disposal container from Novo Nordisk. Learn more.
How you dispose of your sharps container is also important. Follow the guidelines for where you live. To find a sharps disposal location near you, visit safeneedledisposal.org.
Store Wegovy® pens in your refrigerator from 2 °C to 8 °C (36 °F to 46 °F). If needed, before pen cap removal, the Wegovy® pen can be kept outside of the fridge from 8 °C to 30 °C (46 °F to 86 °F) for up to 28 days. Do not freeze Wegovy® and protect it from light. Keep Wegovy® in its original cartons until time of use.
Costs, savings, and support
With the Wegovy® Savings Offer, you may be able to lower your out-of-pocket costs.
Commercially insured patients with coverage for Wegovy® may pay as little as $0 for a one-month supply of Wegovy®.*
If you’re a new self-pay or uninsured patient, you could pay $199 per month for your first 2 months for 0.25 mg or 0.5 mg doses.†
If you’re an existing self-pay or uninsured patient, you can expect to pay $349 for a one-month supply.
See if you can save on Wegovy®.
*28-day supply equivalent to 1 month of treatment. Pay as little as $0 subject to max savings of $225/month. Government beneficiaries excluded. Novo Nordisk reserves the right to modify or cancel this program at any time. See WegovyTerms.com.
†Patients new to the Wegovy® Savings Offer and NovoCare® Pharmacy pay $199 for each month of 0.25 mg and 0.5 mg. Offer only available for 2 monthly fills between 11/17/25-3/31/26. 28-day supply equivalent to 1 month of treatment. Novo Nordisk reserves the right to modify or cancel this program at any time. For eligible patients only. Full terms at NovoCarePharmacyTerms.com and WegovyTerms.com.
Wegovy® may cost less than you think. We have some cost and coverage resources that may help. Learn more.
Your out-of-pocket cost for Wegovy® will depend on a number of factors, for example, your insurance coverage. You can see if you have coverage for Wegovy® and your estimated cost right now. It only takes a few minutes. Check your cost and coverage.
Call the Wegovy® Navigation line at 1-833-4-WEGOVY, Monday through Friday, 9:00 AM to 6:00 PM, ET.
About MASH
MASH is a serious form of fatty liver disease. This means there's an excess buildup of fat in your liver, which, over time, can cause MASH. MASH is a serious condition in which the liver becomes inflamed and damaged (liver cells are enlarged and misshapen).
Certain health conditions are associated with increased risk for MASH, including fatty liver or a family history of cirrhosis, type 2 diabetes or prediabetes, obesity, high blood pressure, high triglycerides (a type of fat), low HDL (good cholesterol), persistently elevated liver enzymes (over 6 months), and PCOS (polycystic ovary syndrome).
MASH is known as a silent disease because it has few or no obvious symptoms, especially early on. Many people living with MASH are unaware they have the disease until it progresses, causing serious liver damage and raising their risk for other major health issues. That’s why it’s important to talk to your HCP about monitoring your liver health.
If left untreated, MASH can lead to liver failure or liver cancer and is also associated with cardiovascular disease. Cardiovascular disease is the leading cause of death in people living with MASH. But when addressed as soon as possible, MASH can often be managed and even improved through lifestyle changes and treatment.
A healthy diet isn't just about what foods you avoid. Within a reduced calorie diet, aim to include more fruits, vegetables, and whole grains, and ask your HCP what other foods support your liver health. Recipes from the Mediterranean diet are a great starting point.
Along with diet, just 2.5 hours of moderate-intensity physical activity a week can make a difference. Keeping active with any type of movement, even walking, can be beneficial to the liver.
Be sure to talk to your HCP about any lifestyle changes you are planning to make.
Important Safety Information
What is the most important information I should know about Wegovy®?
Wegovy® may cause serious side effects, including:
- Possible thyroid tumors, including cancer. Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rodents, Wegovy® and medicines that work like Wegovy® caused thyroid tumors, including thyroid cancer. It is not known if Wegovy® will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people
- Do not use Wegovy® if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
Do not use Wegovy® if:
- you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
- you have had a serious allergic reaction to semaglutide or any of the ingredients in Wegovy®
Before using Wegovy®, tell your healthcare provider if you have any other medical conditions, including if you:
- have or have had problems with your pancreas or kidneys
- have type 2 diabetes and a history of diabetic retinopathy
- have or have had depression, suicidal thoughts, or mental health issues
- are scheduled to have surgery or other procedures that use anesthesia or deep sleepiness (deep sedation)
- are pregnant or plan to become pregnant. Wegovy® may harm your unborn baby. You should stop using Wegovy® 2 months before you plan to become pregnant
- are breastfeeding or plan to breastfeed. It is not known if Wegovy® passes into your breast milk
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Wegovy® may affect the way some medicines work and some medicines may affect the way Wegovy® works. Tell your healthcare provider if you are taking other medicines to treat diabetes, including sulfonylureas or insulin. Wegovy® slows stomach emptying and can affect medicines that need to pass through the stomach quickly.
What are the possible side effects of Wegovy®?
Wegovy® may cause serious side effects, including:
- inflammation of your pancreas (pancreatitis). Stop using Wegovy® and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without nausea or vomiting. Sometimes you may feel the pain from your abdomen to your back
- gallbladder problems. Wegovy® may cause gallbladder problems, including gallstones. Some gallstones may need surgery. Call your healthcare provider if you have symptoms, such as pain in your upper stomach (abdomen), fever, yellowing of the skin or eyes (jaundice), or clay-colored stools
- increased risk of low blood sugar (hypoglycemia), especially those who also take medicines for diabetes such as insulin or sulfonylureas. This can be a serious side effect. Talk to your healthcare provider about how to recognize and treat low blood sugar and check your blood sugar before you start and while you take Wegovy®. Signs and symptoms of low blood sugar may include dizziness or light-headedness, blurred vision, anxiety, irritability or mood changes, sweating, slurred speech, hunger, confusion or drowsiness, shakiness, weakness, headache, fast heartbeat, or feeling jittery
- dehydration leading to kidney problems. Diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration) which may cause kidney problems. It is important for you to drink fluids to help reduce your chance of dehydration. Tell your healthcare provider right away if you have nausea, vomiting, or diarrhea that does not go away
- severe stomach problems. Stomach problems, sometimes severe, have been reported in people who use Wegovy®. Tell your healthcare provider if you have stomach problems that are severe or will not go away
- serious allergic reactions. Stop using Wegovy® and get medical help right away, if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue, or throat; problems breathing or swallowing; severe rash or itching; fainting or feeling dizzy; or very rapid heartbeat
- change in vision in people with type 2 diabetes. Tell your healthcare provider if you have changes in vision during treatment with Wegovy®
- increased heart rate. Wegovy® can increase your heart rate while you are at rest. Tell your healthcare provider if you feel your heart racing or pounding in your chest and it lasts for several minutes
- depression or thoughts of suicide. You should pay attention to any mental changes, especially sudden changes in your mood, behaviors, thoughts, or feelings. Call your healthcare provider right away if you have any mental changes that are new, worse, or worry you
- food or liquid getting into the lungs during surgery or other procedures that use anesthesia or deep sleepiness (deep sedation). Wegovy® may increase the chance of food getting into your lungs during surgery or other procedures. Tell all your healthcare providers that you are taking Wegovy® before you are scheduled to have surgery or other procedures
The most common side effects of Wegovy® may include: nausea, diarrhea, vomiting, constipation, stomach (abdomen) pain, headache, tiredness (fatigue), upset stomach, dizziness, feeling bloated, belching, low blood sugar in people with type 2 diabetes, gas, stomach flu, heartburn, and runny nose or sore throat.
Please see Prescribing Information and Medication Guide for Wegovy®.
Wegovy® is a prescription medication.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
This site is intended for US patients only.
What is Wegovy®?
WEGOVY® (semaglutide) injection 2.4 mg is an injectable prescription medicine used with a reduced calorie diet and increased physical activity to treat adults with metabolic dysfunction-associated steatohepatitis (MASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver.
This indication is approved based on improvement of MASH and liver scarring (fibrosis). There is an ongoing study to confirm the clinical benefit of Wegovy® in adults with MASH.
Wegovy® contains semaglutide and should not be used with other semaglutide-containing products or other GLP-1 receptor agonist medicines.
It is not known if Wegovy® is safe and effective for use for the treatment of MASH in children under 18 years.
What is Wegovy®?
WEGOVY® (semaglutide) injection 2.4 mg is an injectable prescription medicine used with a reduced calorie diet and increased physical activity to treat adults with metabolic dysfunction-associated steatohepatitis (MASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver.
This indication is approved based on improvement of MASH and liver scarring (fibrosis). There is an ongoing study to confirm the clinical benefit of Wegovy® in adults with MASH.
Wegovy® contains semaglutide and should not be used with other semaglutide-containing products or other GLP-1 receptor agonist medicines.
It is not known if Wegovy® is safe and effective for use for the treatment of MASH in children under 18 years.
Important Safety Information
What is the most important information I should know about Wegovy®?
Wegovy® may cause serious side effects, including:
- Possible thyroid tumors, including cancer. Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rodents, Wegovy® and medicines that work like Wegovy® caused thyroid tumors, including thyroid cancer. It is not known if Wegovy® will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people
- Do not use Wegovy® if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
Important Safety Information
What is the most important information I should know about Wegovy®?
Wegovy® may cause serious side effects, including:
- Possible thyroid tumors, including cancer. Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rodents, Wegovy® and medicines that work like Wegovy® caused thyroid tumors, including thyroid cancer. It is not known if Wegovy® will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people
- Do not use Wegovy® if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
Do not use Wegovy® if:
- you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
- you have had a serious allergic reaction to semaglutide or any of the ingredients in Wegovy®
Before using Wegovy®, tell your healthcare provider if you have any other medical conditions, including if you:
- have or have had problems with your pancreas or kidneys
- have type 2 diabetes and a history of diabetic retinopathy
- have or have had depression, suicidal thoughts, or mental health issues
- are scheduled to have surgery or other procedures that use anesthesia or deep sleepiness (deep sedation)
- are pregnant or plan to become pregnant. Wegovy® may harm your unborn baby. You should stop using Wegovy® 2 months before you plan to become pregnant
- are breastfeeding or plan to breastfeed. It is not known if Wegovy® passes into your breast milk
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Wegovy® may affect the way some medicines work and some medicines may affect the way Wegovy® works. Tell your healthcare provider if you are taking other medicines to treat diabetes, including sulfonylureas or insulin. Wegovy® slows stomach emptying and can affect medicines that need to pass through the stomach quickly.
What are the possible side effects of Wegovy®?
Wegovy® may cause serious side effects, including:
- inflammation of your pancreas (pancreatitis). Stop using Wegovy® and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without nausea or vomiting. Sometimes you may feel the pain from your abdomen to your back
- gallbladder problems. Wegovy® may cause gallbladder problems, including gallstones. Some gallstones may need surgery. Call your healthcare provider if you have symptoms, such as pain in your upper stomach (abdomen), fever, yellowing of the skin or eyes (jaundice), or clay-colored stools
- increased risk of low blood sugar (hypoglycemia), especially those who also take medicines for diabetes such as insulin or sulfonylureas. This can be a serious side effect. Talk to your healthcare provider about how to recognize and treat low blood sugar and check your blood sugar before you start and while you take Wegovy®. Signs and symptoms of low blood sugar may include dizziness or light-headedness, blurred vision, anxiety, irritability or mood changes, sweating, slurred speech, hunger, confusion or drowsiness, shakiness, weakness, headache, fast heartbeat, or feeling jittery
- dehydration leading to kidney problems. Diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration) which may cause kidney problems. It is important for you to drink fluids to help reduce your chance of dehydration. Tell your healthcare provider right away if you have nausea, vomiting, or diarrhea that does not go away
- severe stomach problems. Stomach problems, sometimes severe, have been reported in people who use Wegovy®. Tell your healthcare provider if you have stomach problems that are severe or will not go away
- serious allergic reactions. Stop using Wegovy® and get medical help right away, if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue, or throat; problems breathing or swallowing; severe rash or itching; fainting or feeling dizzy; or very rapid heartbeat
- change in vision in people with type 2 diabetes. Tell your healthcare provider if you have changes in vision during treatment with Wegovy®
- increased heart rate. Wegovy® can increase your heart rate while you are at rest. Tell your healthcare provider if you feel your heart racing or pounding in your chest and it lasts for several minutes
- depression or thoughts of suicide. You should pay attention to any mental changes, especially sudden changes in your mood, behaviors, thoughts, or feelings. Call your healthcare provider right away if you have any mental changes that are new, worse, or worry you
- food or liquid getting into the lungs during surgery or other procedures that use anesthesia or deep sleepiness (deep sedation). Wegovy® may increase the chance of food getting into your lungs during surgery or other procedures. Tell all your healthcare providers that you are taking Wegovy® before you are scheduled to have surgery or other procedures
The most common side effects of Wegovy® may include: nausea, diarrhea, vomiting, constipation, stomach (abdomen) pain, headache, tiredness (fatigue), upset stomach, dizziness, feeling bloated, belching, low blood sugar in people with type 2 diabetes, gas, stomach flu, heartburn, and runny nose or sore throat.
Please see Prescribing Information and Medication Guide for Wegovy®.
Wegovy® is a prescription medication.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
This site is intended for US patients only.
What is Wegovy®?
WEGOVY® (semaglutide) injection 2.4 mg is an injectable prescription medicine used with a reduced calorie diet and increased physical activity to treat adults with metabolic dysfunction-associated steatohepatitis (MASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver.
This indication is approved based on improvement of MASH and liver scarring (fibrosis). There is an ongoing study to confirm the clinical benefit of Wegovy® in adults with MASH.
Wegovy® contains semaglutide and should not be used with other semaglutide-containing products or other GLP-1 receptor agonist medicines.
It is not known if Wegovy® is safe and effective for use for the treatment of MASH in children under 18 years.
